Research Mentors
Biomedical Sciences
Phillip Kramer
How hormone levels (directly and indirectly) lead to changes in immune reactions and pain responses in the TMJ. Sex hormones and regulation of the immune response in patients with auto-immune disorders. Use of mesenchymal stem cells or multi-potent adult progenitor cells for repair or replacement of damaged tissues in the oral cavity. Determine the stem cell's potential to differentiate into specific oral cell types and determine the mechanistic processes by which these stem cells transform.
Sufang Liu
Bob Lu
Odontogenesis to study how cranial neural crest cells migrate to the frontonasal processes and first branchial arches and how they interact reciprocally with the dental epithelium and differentiate into the odontoblasts forming dentin.
Chunlin Qin
Investigate the roles of the extracellular matrix (ECM) proteins in the formation and mineralization of dentin (the bulk tissue shaping the contour of a tooth) and bone. Seeking to understand the overall processes of tooth and bone formation by focusing upon the nature, metabolism, tissue/cell localization and functions of the ECM molecules in dentin and bone, two tissues that resemble each other in composition and mechanisms of formation.
Bruno Ruest
Understand how improper regulation of neural crest cells (NCC) development leads to birth defects. Understand how NCCs are formed, what initiates the expression of NCC-specific genes, what regulates their migration and final destination and how they differentiate into proper structures by activating specific genes and establish structural identity. Use different genetic, molecular and cellular biology tools to study craniofacial and cardiovascular development during mouse embryogenesis with emphasis on the endothelin system.
Emet Schneiderman
Craniofacial biology; use of digital imaging and biostatistics to illuminate growth and development of the facial skeleton, particularly in cleft patients. Use and efficacy of appliance in sleep apnea treatment.
Kathy Svoboda
Interested in the role of the cytoskeleton in cell shape changes throughout her career. Has developed experimental approaches to examine the spatial relationships between specific cellular components in whole tissues. These cellular models have been used to determine the three-dimensional relationships between organelles, cytoskeletal proteins and specific mRNA.
Feng Tao
Central mechanisms of pain transmission and analgesia. Antinociceptive effect of motor cortex stimulation using optogenetics. Stem cell therapy for spinal cord injury-induced chronic neuropathic pain. Neural circuits related to pain sensation using optogenetic manipulation combined with multi-channel recording in freely behaving mice.
Qian Wang
Craniofacial region (function, adaptation, biomechanics). Bone and muscle biomechanics in the craniofacial region, bone biology. Broadly concerned with the growth, adaptation, and evolution of the craniofacial skeleton and related soft tissues. Functional results of surgical and traumatic insults on the basic structures and function of the craniofacial skeleton.
Xiaofang Wang
Dissect the signaling pathways involving FGF23 and the specific roles of each molecule in the pathways associated with the development of bone and tooth. Investigate the reciprocal interactions mediated by FAM20 molecules between hematopoietic cells and osteoblast cells.
Hua Zhang
My research interests include the Roles of bone morphogenetic protein 1 (BMP1)/tolloid-like I (TLL1) proteinases in dentinogenesis and the roles of FAM20C (Family with sequence similarity 20, member C) and SIBLING (small integrin binding ligands N-linked glycoprotein) family proteins in brain homeostasis.
Endodontics
Hongjiao Ouyang
“I am fascinated by the protein-folding machinery and its role in the pathogenesis of skeletal and oral inflammatory diseases,” she says. “The organic extracellular matrix proteins in bone and teeth, such as type I collagen, must be adequately assembled inside a cell’s endoplasmic reticulum in order to execute their biological functions. The ER stress signaling network is a central regulator for protein folding and trafficking.” Ouyang presents at NIDCR 70th anniversary symposium
General Dentistry
Orthodontics
Matthew Kesterke
Craniofacial region (function, adaptation, biomechanics). Bone and muscle biomechanics in the craniofacial region, bone biology. Broadly concerned with the growth, adaptation, and evolution of the craniofacial skeleton and related soft tissues. Functional results of surgical and traumatic insults on the basic structures and function of the craniofacial skeleton.
Reginald Taylor
Architecture and control of collagen expression in the periodontal ligament.
Yan Jing
Dr. Yan Jing is a clinician scientist who was trained in both basic and clinical sciences directly linked to mandibular biology and orthodontics. Dr. Jing performs researches in craniofacial biology and orthodontics. Her major contribution to the field is to demonstrate that direct transdifferentiation of chondrocytes into bone cells is a critical event during condyle development, rather than the old concept of hypertrophic chondrocyte apoptosis followed by bone marrow cell invasion. The publication entitled “Chondrocytes Directly Transform into Bone Cells in Mandible Condyle Growth” was selected as the cover of the year in JDR 2015 and William J. Gies Award for Biological Research in JDR 2017 (JDR, Journal of Dental Research, the best one in dentistry). In another study about condyle formation and remodeling, Dr. Jing’s group identified that tendon cells, beyond their role in joint movement, function as key precursors for TMJ disc formation, condyle growth, and joint remodeling.
Pediatrics
Periodontics
Public Health Sciences
Amal Noureldin
Carious lesions. Fluoride. Cariology issues.
Peggy Timothy
Intra office selfies, taken by patients, will be assessed for pre-defined characteristics
Contact Information
Dr. Shannon Kramer
Texas A&M School of Dentistry
3302 Gaston Avenue
Dallas, TX 75246